The results showed that expression of TXNDC12 (HR = 1.604, 95%CI = 1.178–2.182, p < 0.005) and WHO grade of glioma (HR = 2.059, 95% CI = 1.158–3.662, p < 0.05) were risk factors for glioma patients. This evidence concerns the gene TXNDC12 and glioma.