In 1984, we demonstrated that PARP inhibitors induced the regeneration of pancreatic β-cells in 90% depancreatized rats, thereby ameliorating the surgical diabetes.154,156) Male Wistar rats were 90% depancreatized and, beginning 7 days before the partial pancreatectomy and continuing post-operatively, nicotinamide (0.5 g/kg body weight) or 3-aminobenzamide (0.05 g/kg body weight) was injected intraperitoneally every day. Here, PARP1 is linked to diabetes mellitus.