It has been suggested that the growth of NSCLC cells (A549, PC9, H1299, H1650, and H1975) was prevented by emodin (less than125 μM) since emodin reduced ILK expression by up-regulating MAPK extracellular signaling-regulated kinase (MEK)/ERK1/2 and AMP-activated protein kinase (AMPK)α signaling pathway, as well as decreasing the expression of specificity protein 1 (Sp1) and c-Jun protein [115]. This evidence concerns the gene SP1 and non-small cell lung carcinoma.