TRAF6 and thyroid gland undifferentiated (anaplastic) carcinoma: Emodin (less than 40 μM) dose-dependently suppressed both TRAF6/HIF-1α/VEGF and TRAF6/CD147/MMP9 signaling pathways to simultaneously inhibit pro-angiogenesis and invasion capacity of human anaplastic thyroid cancer cell lines (8505c and SW1736) [132].