Emodin (20 or 40 mg/kg in vivo and 10–40 μM in vitro) inhibited mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1α)/VEGF signaling pathway and alleviated inflammation in rats with LPS-induced ALI and RAW264.7 cells [54]. The gene discussed is VEGFA; the disease is acute respiratory distress syndrome.