In addition, emodin (20–80 μM and 10–200 μM respectively) was reported to induce apoptosis of hepatocellular carcinoma (HCC) by suppressing PI3K/AKT and promoting the phosphorylation of p38 in HCC cell lines (SMMC-7721 and HepG2) [93, 94]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.