NLRP3 and acute respiratory distress syndrome: further determined that emodin (40 mg/kg) markedly mitigated SAP-upregulated cold-inducible RNA-binding protein expression and NLRP3 inflammasome formation to attenuate progressive pulmonary neutrophil infiltration in SAP-ALI rats, via deactivating NLRP3/IL-1β/CXCL1 signal [49].