NFKB1 and cancer: Moreover, intracellular serine/threonine kinase integrin-linked kinase (ILK) is highly expressed in malignancies and recognized as a central regulator of signaling cascades that controls a series of biological processes in cancer progression, including but not limited to PI3K/AKT, Hippo, NF-κB, ERK and BCL-2 signals [114].