FLNA and Melnick-Needles syndrome: The patients inherited from the mother the FLNA gene carrying a c.622G>C nucleotide change, that leads to the aminoacidic substitution p.Gly208Arg in the N-terminal domain of Filamin A. The mother was affected as well by MNS, but, due to a milder phenotype, she was diagnosed only after her offspring received the diagnosis.