Through colocalization, we further showed that the effect of rs1837253 genotype on risk for asthma may be mediated through DNA methylation levels at CpG sites in the untranslated first exon of the TSLP gene in AECs, suggesting an epigenetic mechanism of disease that is robust to RV and vehicle treatment and contributes to both adult and childhood onset asthma. The gene discussed is TSLP; the disease is asthma.