Previous studies have shown that SNPs at this extended locus are eQTLs for at least four genes (ORMDL3, GSDMB, GSDMA, PGAP3) in blood and/or lung cells [10] and that their genotype effects on risk for childhood onset asthma are modified by early life wheezing illness in general [11, 12, 85] and RV-associated wheezing illness in particular [13]. This evidence concerns the gene GSDMB and asthma.