Three of the 11 pairs in the adult and childhood onset GWAS and one of the eight pairs in the TAGC GWAS included an intergenic SNP (rs1837253) located 5.7 kb upstream from the transcriptional start site (TSS) of the TSLP gene on chromosome 5q22, encoding an epithelial cell cytokine that plays a key role in the inflammatory response in asthma and other allergic diseases [82]. Here, TSLP is linked to allergic disease.