To further assess the influence of cerebral ischemia on the activation of TAK1 and the inflammasomes NLRP3, NLRC4, and AIM2, we first compared the protein expression of TAK1 and its phosphorylation (pTAK1) in mice after tMCAo or sham surgery (Fig. 3A). The gene discussed is MAP3K7; the disease is Cerebral ischemia.