A recent literature search on NCBI (15th January 2021) using the search terms “NLRP3,” “NLRC4,” and “AIM2” in combination with “stroke,” “tMCAo,” and “cerebral ischemia” revealed 15–25 times the number of studies for NLRP3 (263) than for NLRC4 (10) and AIM2 (15). This evidence concerns the gene NLRP3 and stroke disorder.