TP53 and hepatocellular carcinoma: Bbc3/Puma, a pro-apoptotic p53 target gene that has been shown to play a role in modulating liver metabolism in human HCC [46], was not differentially expressed between Albumin-Cre; p53WT/WT and Albumin-Cre; p53FL/FL mice during CCl4-mediated regeneration (Fig. S2G), reinforcing the idea that not all aspects of p53 activity are engaged during liver regeneration.