The immunohistochemical results showed that caspase 3 was significantly upregulated in the solid tumors of the mice injected with NME2 KO, while Ki67 was not detected in the NME2 KO treatment (Fig. 5e), indicating that NME2 was required for anti-apoptosis of gastric cancer stem-like cells. Here, NME2 is linked to gastric cancer.