Our group have performed a series of studies in a population with occupational exposure to BD and found that BD exposure was associated with the increased genotoxic damage for multiple endpoints in peripheral blood lymphocytes of workers, including HPRT mutation and formation of micronucleus (MN), nucleoplasmic bridge (NPB) and nuclear bud (NBUD) [3, 4]. The gene discussed is HPRT1; the disease is Behcet disease.