For instance, cancer cells release EVs containing multidrug resistance protein 1 (MDR-1), a drug efflux pump, and treatment with those MDR-1 containing EVs facilitates the survival of various cancer cells, including prostate and ovarian cancers, acute T lymphoblastic leukemia, and osteosarcoma cells [49–52]. The gene discussed is ABCB1; the disease is osteosarcoma.