Accordingly, one animal study [23] demonstrated that cinnamon powder (10 mg/100 g body) for 20 days decreased the IGF-1 level, while it increased the Insulin-like growth factor-binding protein (IGFBP-1) level in plasma, as well as in the ovary, according to the PCOS mice model. Here, IGFBP1 is linked to polycystic ovary syndrome.