GSTM1 and Splenomegaly: A 36-year-old man was referred for moderate macrocytic anemia with inadequate reticulocytosis (Hb 9.8 g/dL, mean corpuscular volume 106 fL, 80 × 109/L reticulocytes), mild hemolytic features (LDH 1.2 × upper limit of normality, unconjugated bilirubin 1.2 mg/dL, undetectable haptoglobin), and splenomegaly (18 cm by ultrasound).