Among rarer CHAs, it is worth mentioning several ultra-rare enzyme defects (glucosephosphate isomerase, GPI, phosphofructokinase, PFK, adenylate kinase, AK, triosephosphate isomerase, TPI, phosphoglycerate kinase, PGK, hexokinase, HK, and pyrimidine 5′-nucleotidase, P5N), and congenital dyserythropoietic anemias (CDA), mostly recessive conditions. This evidence concerns the gene TPI1 and congenital dyserythropoietic anemia.