Importantly, all adjuvanted vaccines (notably γ-Flu-CCL21-Poly (I:C) platform) afforded higher levels of IFN-γ and IL-12 expression than that of IL-4, indicating that vaccine adjuvant incorporation strategy could elicit more potent Th1 and Th2 balanced responses, with more biased toward Th1, to γ-inactivated influenza vaccine. Here, CCL21 is linked to influenza.