EZR and pachyonychia congenita: The GEO and TCGA databases were utilized to measure the expression of different genes in PC and normal pancreatic tissues, the differentially expressed genes were shown in Fig. 1A–C, Venn diagram of the differentially expressed genes in the three microarray datasets was shown in Fig. 1D, we obtained three target genes S100P, EZR and TFF1, then Kaplan–Meier survival analysis demonstrated that PC patients with high expression of EZR was positively correlated with diagnosis in overall survival rate (OS) and disease free survival (DFS) according to GEPIA database (Fig. 1E, F).