ASXL1 and acute myeloid leukemia: The median EFS in single-hit ASXL1+ AML was not attained in single-hit ASXL1+ AML, 29.53 months in double-hit ASXL1+ AML, and 5.47 months in triple-hit ASXL1+ AML (P = 0.003, Fig. 2B).