Hyaline fibromatosis syndrome (HFS; MIM# 228600) is a rare autosomal recessive disorder of the connective tissue caused by mutations in the gene for anthrax toxin receptor-2 (ANTXR2), also known as capillary morphogenesis protein 2, located on chromosome 4q21 [1–3]. This evidence concerns the gene ANTXR2 and hyaline fibromatosis syndrome.