Significant differences in sharp score were found between RA patients with ESR (p = 0.000), CRP (p = 0.023), RF (p = 0.000), indicating that ESR, CRP, RF were risk factors for sharp score, the higher expression of ESR, CRP, RF, the high score of sharp (Fig. 2). The gene discussed is ESR1; the disease is rheumatoid arthritis.