An intracerebroventricular injection of the diabetogenic toxin streptozotocin (icv-STZ) exacerbates memory disturbances and AD-like neurochemical changes in the brains of 3 × Tg-AD mice (harboring the PS1M146V, APPswe and TauP30IL transgenes) by impairing insulin signaling [26, 27]. The gene discussed is INS; the disease is Alzheimer disease.