CEACAM5 and neoplasm: LND, POD time > 9 d, CEA > 7 ng/mL, CA 19–9 > 75 U/mL, operation time > 235 min, blood loss > 300 mL, tumor size > 6 cm, multi-disease, positive margin, differentiation, vascular invasion, nerve invasion, and T stage > T1 were the primary factors influencing DFS.