Additionally, CSF-1 expression was negatively linked to miR-485-5p expression but positively linked to circCDC45 expression in GBM tissues, and circCDC45 downregulation weakened CSF-1 expression, while miR-485-5p inhibition recovered CSF-1 expression, suggesting that circCDC45 regulated CSF-1 by targeting miR-485-5p. Here, CSF1 is linked to glioblastoma.