Following UGCG inhibition, no alterations of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and rapidly accelerated fibrosarcoma (RAF)/ mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling could be detected in liver cancer cells [33]. The gene discussed is AKT1; the disease is fibrosarcoma.