Markers identifying T helper cells (CD4), cytotoxic T cells (CTLs) (CD8), T regulatory cells (T regs) (FoxP3), B‐cells (CD20), macrophages (CD80, CD163, and CD68), and neutrophils (CD66b) were included to investigate these cell subsets in tumor‐associated stroma and their intra‐tumoral infiltration, in addition to PD‐L1 biomarker chosen as a surrogate marker for activation of the tumor suppressive mechanism. This evidence concerns the gene CD4 and neoplasm.