DHFR and Hepatic fibrosis: Notably, INPP5D (also known as SHIP1, a potent negative regulator of the PI3K pathway which correlates inversely with histological stages of liver fibrosis) was up‐regulated significantly (Log2 fold change = 1.08, p = 0.0128) in activated Lx‐2 cells with DHFR silence when compared with that in activated Lx‐2 cells without DHFR silence (siRNA‐DHFR + TGF‐β vs. siRNA‐NC + TGF‐β).