To identify signaling cascade downstream of PCID2-PML interaction, we measured the activity of eight cancer-related pathways by luciferase reporter assay, revealing that PCID2 dramatically activated Top-flash (Wnt/β-catenin) but suppressed p53 signaling, which was also evidenced by enhanced c-Myc and decreased p53 protein, respectively. Here, TP53 is linked to cancer.