Besides, PCID2 promotes cell migration/invasion of CRC cells in vitro and formation of lung metastases in nude mice, which is attributed to the induction of epithelial-mesenchymal transition (EMT) by PCID2, thus favoring a mesenchymal phenotype with increased migratory and invasive potential [24–27]. This evidence concerns the gene PCID2 and colorectal carcinoma.