As shown in Fig. 3, MMP-3 levels were positively correlated with SBP in people with obesity (r = 0.21, p = 0.017, Fig. 3c), however, no significant correlation was noted among non-obese and overweight people (r = 0.12, p = 0.26; r = 0.18, p = 0.31, Fig. 3a,b, respectively). This evidence concerns the gene MMP3 and obesity due to melanocortin 4 receptor deficiency.