Binary logistic regression setting obesity and metabolic syndrome status as dependent variables and MMP (-1, -2, -3 and -9), TIMP (-1 and -2) and MMP/TIMP ratios (MMP-1/TIMP-1, MMP-2/TIMP-2, MMP-3/TIMP-1 and MMP-9/TIMP-1) as independent variables revealed a significant association of MMP-2, TIMP (-1 and -2) and MMP-2/TIMP-2 ratio when obesity status was considered as a dependent variable (Supplementary Table 1). The gene discussed is MMP1; the disease is obesity due to melanocortin 4 receptor deficiency.