ANGPT1 and Parkinson disease: C16 or Ang-1 alone ameliorated functional impairment in PD animals, while the combination of C16 and Ang-1 exhibited more potent therapeutic effects including a reduction in the mean velocity of both animal models in the open field test, decreased distance traveled in 6-OHDA-treated rats, and increased time on the rotarod test device in MPTP-treated mice (Fig. 1a–f).