However, the model groups showed a significantly higher level of phospho-DARPP-32 compared to normal controls, while C16 alone, Ang-1 alone, and especially C16 plus Ang-1 remarkably suppressed the expression phospho-DARPP-32 in PD model animals (Fig. 15c, d, Supplementary Fig. 9). The gene discussed is ANGPT1; the disease is Parkinson disease.