Consistent with our previous finding, A4-IgG2b, which is similar to αCD47-G1 that has a stronger Fc receptor binding affinity36–39, induced a significantly higher level of macrophage phagocytosis against GBM cells compared to A4-IgG3, which is similar to αCD47-G4 nearly lacking Fc receptor binding ability36–39 (Supplementary Fig. 15a, b). The gene discussed is IGHG3; the disease is glioblastoma.