SIRPA and neoplasm: Experimentally, the local delivery of OV-αCD47-G1 leads to (1) direct tumor lysis by oHSV; (2) innate immune cell infiltration and activation at the TME by oHSV; (3) blockade of the “don’t eat me” signal normally mediated by the interaction between SIRPα and CD47 expressed by macrophages and GBM cells, respectively; (4) αCD47-G1-mediated ADCP via bridging Fcγ receptors on macrophages and CD47 on GBM cells; and (5) αCD47-G1-mediated ADCC by NK cells.