MYD88 and neoplasm: Indeed, Otulinfl/flK14-Cre Myd88−/− mice (hereafter referred to as OTULINE-KO; Myd88−/−) were strongly protected from skin lesion development and most of these animals remained lesion-free until the age of about 14 weeks (Fig. 8a, b and Supplementary Fig. 8a).