Dermatitis in ΔKerOTULIN skin was further confirmed by the marked presence of CD11b- and F4/80-positive macrophages in ΔKerOTULIN skin lesions (Fig. 1e), and aberrant keratinocyte differentiation could be demonstrated in both lesional and non-lesional skin of ΔKerOTULIN mice based on abnormal Keratin-6 (K6) and filaggrin staining of skin sections (Fig. 1e). The gene discussed is FLG; the disease is skin disorder.