OTULINL272P/L272Pcasp8−/−RIPK3−/− mice were born in Mendelian numbers and developed normally without any sign of inflammation (Table 1, Fig. 7b, c) with the exception of the lymphoproliferative syndrome that develops in Casp8−/−RIPK3−/− mice, as previously shown39,40. The gene discussed is CASP8; the disease is lymphoproliferative syndrome.