While it is known that PHLDA1/TDAG51 is induced by the UPR and is necessary for the development of TGF-β adenovirus-mediated peritoneal fibrosis [16], the mechanism by which TDAG51 affects the progression of fibrosis, and specifically renal interstitial fibrosis in CKD, has not yet been studied. The gene discussed is PHLDA1; the disease is chronic kidney disease.