Our mouse model of CKD altered the expression of a number of UPR genes, namely Edem1, Fkbp65, Hsp27, Hsp47, and Phlda1. While all of these genes play some role in the UPR, not all have fibrotic effects like those found in our model of CKD; further, the mechanisms and downstream effects of some are more understood than others. Here, EDEM1 is linked to chronic kidney disease.