PIK3CA and hepatocellular carcinoma: Thus, two HCC cell lines with relatively low expression of PI3K and high expression of c-MET, namely SNU449 and SNU387 cells (Supplementary Fig. S3), were transfected with PIK3CA mutants, PIK3CAH1047R (H1047R) and PIK3CAE545K (E545K), to test this hypothesis.