The results of CyTOF and scRNA-seq of melanoma tumors present that the deletion of GCN2 alters the phenotype of macrophages and MDSCs by increasing the translation of CREB-2/ATF4, resulting in the loss of their inhibitory function and the enhancement of anti-tumor immunity of CD8+ T cell in vivo [90]. The gene discussed is ATF4; the disease is neoplasm.