30% ~ 40% CAFs are generated from endothelial cells through endothelial-to-mesenmal transition, and could secrete HSP90α to induce M2 polarization and promote tumor progression [145], which can be abrogated by Octyl gallate by blocking HSP90Α-TLR4 ligation [146]. The gene discussed is HSP90AA1; the disease is neoplasm.