In addition, the combination of bromodomain inhibitor JQ1 and Ricolinostat can promote anti-tumor immunity in the mouse model of non-small cell lung cancer, the former specifically reduce the expression of Foxp3, CTLA-4 and PD-1 in Tregs and weaken its immunosuppressive function, while the latter could promote the expression of MHC and costimulatory molecule CD86 in macrophages [143]. The gene discussed is PDCD1; the disease is neoplasm.