CXCL8 and triple-negative breast carcinoma: Utilizing IL-8 neutralizing antibody HuMax-IL8 in patients with advanced malignant solid tumors has been tested in phase I clinical trial (NCT02536469), [45], and the CXCR1/2 antagonist Reparixin combined with Paclitaxel in patients with metastatic triple negative breast cancer has passed Phase I clinical trial [40], and its Phase II clinical trial has been launched (NCT02370238).