Furthermore, given that CD169+ macrophages rely on CD169 to transfer antigen to BATF3 signaling-dependent DCs to initiate CD8+ T cell immune response [119], delivering melanoma antigen to CD169 to induce DCs antigen presentation and trigger specific T cell responses, is an interesting attempt to systematically improve the defect of antigen presentation to circumvent the limitations of intratumoral myeloid targeting [120]. This evidence concerns the gene CD8A and melanoma.