Tregs induce tumor-promoting activation of monocytes or macrophages through cell contact or secreting IL-10 [139], while flow cytometry analysis and immunohistochemistry of the MHCI-deficient mouse lymphoma demonstrated that Tregs deletion promote tumor cells to express MHCII and secrete cytokines and chemokines, enhancing anti-tumor activities [140]. This evidence concerns the gene IL10 and neoplasm.