In high-risk metastatic neuroblastoma model treated with a small molecule inhibitors targeted at microsomal prostaglandin E synthesis-1 (mPGES-1), immunohistochemical staining revealed a decrease in CD206 positive tumor-promoting M2 macrophages in tumors by blocking CAF-derived PGE2, which avoids adverse effect of current clinical PGE2-targeting drugs to reduces tumor growth [151]. This evidence concerns the gene MRC1 and neoplasm.