A significant upregulation of TNFR1 (Ctrl: 1.74 ± 0.25, AD:3.75 ± 0.38; p = 0.0002) and TNFR2 (Ctrl:0.17 ± 0.04, AD: 0.51 ± 0.05; p < 0.0001) gene expression, but no change in FADD gene expression, was observed in the AD brain compared to controls (Fig. 5a). Here, FADD is linked to Alzheimer disease.