There was a two–threefold increase in the mRNA expression levels for RIPK1 (mean ± SEM AD: 0.8 ± 0.18, Ctrl: 0.2 ± 0.06; p = 0.0152), RIPK3 (AD: 1.3 ± 0.14, Ctrl: 0.5 ± 0.15; p = 0.0007) and MLKL (AD: 1.33 ± 0.15, Ctrl: 0.68 ± 0.12; p = 0.0057) in AD cases (Fig. 1a). This evidence concerns the gene RIPK3 and Alzheimer disease.