VPS4B and Alzheimer disease: Gene expression analysis of the essential components of the ESCRT III complex (CHMP2a, CHMP2b, VPS24/CHMP3, CHMP4b and CHMP6) and VPS4b, which is important for recycling the ESCRT-III components, showed that VPS4b and CHMP3 had significantly higher expression in the AD brains compared to the controls (Fig. 7a, Additional file 3: Figure 3a).