TNF and Alzheimer disease: While our results indicate that TNF-TNFR1 interaction may be a key mechanism that drives neurodegeneration in AD, it is important to note that there are other triggers and pathways leading to necroptotic cell death such as FasL, TRAIL, dsRNA/PKR, and viral Z-RNA [28, 41, 73], although their role in neuronal loss in AD is yet to be investigated.