Next, to determine whether a decrease in PLCβ1 protein levels correlates with hippocampus-dependent memory impairment in a mouse model of AD, we performed a contextual fear memory task in the DMSO-injected WT, DMSO-injected 5XFAD, and m-3M3FBS-injected 5XFAD mice (Fig. 4d). Here, PLCB1 is linked to Alzheimer disease.