PLCB1 and Alzheimer disease: We used the 5XFAD mouse model of AD, which is known as a representative rodent model that mimics AβO pathophysiology in AD [42], to examine whether (1) PLCβ1 protein levels are affected in 5XFAD mice and if so, whether these can be restored pharmacologically using m-3M3FBS and (2) whether contextual fear memory, a well-known hippocampal-dependent behavioral assay [65, 66] which is known to be impaired in 5XFAD mice [67, 68], can also be restored by PLCβ activation.