Previous studies have provided preliminary evidence that targeting MUS81 could sensitize several chemotherapeutic drugs in cancer cells [39, 40]; in addition, our previous study reported that MUS81 could serve as a therapeutic target for the BRD4 inhibitor AZD5153 via regulation of Sirt5 [26], although its therapeutic potential needs to be further discussed in gastric cancer. The gene discussed is SIRT5; the disease is gastric cancer.