NKX3.1 is also a tumor suppressor gene, situated on chromosome 8p21.2, which shows loss of heterozygosity (LOH) in up to 89% of high-grade prostatic intraepithelial neoplasia (HG-PIN) and up to 86% of prostatic tumors [20]. The gene discussed is NKX3-1; the disease is prostate intraepithelial neoplasia.