The minor allele distribution was significantly different (p-value < 0.05) between the keratoconus and main control groups for all three SNPs: rs1536482 near the COL5A1 gene, rs2721051 near the FOXO1 gene, and the rs1324183 minor allele near the MPDZ gene (Table 5). The gene discussed is COL5A1; the disease is keratoconus.