Here, we found that loss of STK25 protected against hepatic macrophage infiltration in both DEN- and CDAA-induced models of HCC as evidenced by a lower number of F4/80- and Gr1 (Ly6C)-positive cells in the liver sections from Stk25-/- vs wild-type mice (Figure 5A and B). Here, STK25 is linked to hepatocellular carcinoma.