Notably, STK25 belongs to the GCKIII subfamily of sterile 20-type kinases together with 2 closely related kinases MST3 (also known as STK24) and MST4, which all are associated with lipid droplets in the liver and have similar functions regulating hepatocyte lipotoxicity and metabolic stress response in the context of obesity.12, 13, 14,17,55, 56, 57 It therefore is possible that antagonizing the activity of all 3 of these GCKIII kinases may promote the anti-HCC effect further. Here, STK24 is linked to hepatocellular carcinoma.