Our recent translational studies have identified the liver lipid droplet–decorating protein kinase serine/threonine kinase 25 (STK25, also referred to as YSK1 or SOK1) as a new regulator of hepatic lipid partitioning.11, 12, 13, 14, 15, 16, 17 Furthermore, we found that STK25 critically controls liver meta-inflammation, oxidative and endoplasmic reticulum (ER) stress, as well as the autophagic degradation system,12, 13, 14, 15, 16, 17 which all have been described as key factors leading to HCC development in the context of NASH.8 This evidence concerns the gene STK25 and metabolic dysfunction-associated steatohepatitis.