Consistent with these morphologic investigations in whole-liver samples, we found less-extensive damage in H&E-stained liver sections from Stk25-/- vs wild-type mice, associated with a significantly reduced labeling for HCC markers α-fetoprotein (AFP) and Yes-associated protein (YAP) (Figure 1D and E).28 The gene discussed is STK25; the disease is hepatocellular carcinoma.