MAPK8 and hepatocellular carcinoma: To explore the mechanisms by which STK25 depletion protects against hepatocellular carcinogenesis, we performed immunoblot analysis in the liver tumors isolated from mice with DEN-induced HCC to monitor the hepatic activation status of mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase 1/2 (ERK1/2), Jun N-terminal kinase (JNK), and p38, which are important signaling components controlling proliferation, differentiation, and migration in HCC.41