In particular, ALS-associated RBPs, FUS, TDP-43, hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1), hnRNP A2/B1, hnRNPA3, EWSR1 (Ewing's sarcoma RNA binding protein 1), and TIA1 (T cell-restricted intracellular antigen-1) have been suggested to exhibit RNP granules mediated by LLPS (28, 33, 47, 58, 59, 60, 61, 62). This evidence concerns the gene EWSR1 and amyotrophic lateral sclerosis.