STAT3 and familial pancreatic carcinoma: Furthermore, microRNA-216a has been reported to be one of the inhibitors of JAK2-STAT3 [31], and its therapeutic mechanism and effect of treating pancreatic cancer were similar to panaxadiol, which reduced the expression of p-JAK2 and p-STAT3 of pancreatic cancer cells and block cancer progression in vivo and in vitro.