Series of assays experimentally presented that though MSC-EV delivering miR-34a-5p-mimic depressed CRC cell growth and EMT process, another transfection of oe-c-MYC into MSC-EV would abrogate the therapeutic effects of miR-34a-5p-mimic (Fig. 8A-H). Here, MYC is linked to colorectal carcinoma.