The significant difference in calprotectin level (P < 0.001) between peri-implantitis and healthy groups was more marked than those of IL-1β (P = 0.002 or P = 0.02) and IL-6 (P = 0.049 or P = 0.02) [30, 37], suggesting that calprotectin in PICF is a possible marker for diagnosing peri-implant diseases with inflammation. Here, IL6 is linked to Peri-Implantitis.