DKK1 and cancer: TSPAN8 (tetraspanin 8; FC − 1.87), DKK1 (dickkopf‐1; FC − 1.76), NDNF (neuron-derived neurotrophic factor; FC − 1.75) and RPPH1 (ribonuclease P RNA component H1; FC − 1.75) have been shown to promote cancer cell stemness, elevate angiogenesis, increase EMT, inhibit Th1 polarization, and suppress IFN-γ secretion in cancers [10–13], suggesting that D + T may have a broader effect on different types of biological pathways than D alone.