However, another study found that the endogenously produced 5-androstene-3β, 17β-diol, an ERβ agonist, protects against neuroinflammation in the rotenone-induced rat model of PD [143], suggesting that type of PD model and type of selective ER modulators may influence the neuroprotective readouts. The gene discussed is ESR1; the disease is Parkinson disease.