ESR2 and Alzheimer disease: Furthermore, studies using the 3xTg mouse model of AD demonstrated that selective ERβ activation is more effective than ERα activation in lowering Aβ levels in the frontal cortex and equally effective in the amygdala [117], and that long-term ERβ treatment improved spatial recognition memory, attenuated Aβ plaque formation, prolonged survival, and promoted physical health in these mice [127].