(“Diabetes Mellitus, Type 2”/exp OR “Type 2 Diabetes Mellitus” OR “NIDDM” OR “Type 2 Diabetes”) AND (“glucokinase activator”/exp OR “ Dorzagliatin”:ti,ab,kw OR “ HMS5552”:ti,ab,kw OR “ Piragliatin”:ti,ab,kw OR “RO4389620”:ti,ab,kw OR “ AMG 151”:ti,ab,kw OR “ARRY-403”:ti,ab,kw OR “ AZD1656”:ti,ab,kw OR “ AZD6370”:ti,ab,kw OR “ TMG-123”:ti,ab,kw OR “MK-0941”:ti,ab,kw OR “ TTP-399”:ti,ab,kw OR “SY004”:ti,ab,kw OR “ GKM001”:ti,ab,kw) AND ’randomized controlled trial’/de. This evidence concerns the gene GCK and type 2 diabetes mellitus.