CD4 and ovarian carcinoma: Dendritic cells (DCs) are professional antigen presenting cells that endocytose exogenous antigens[33] and have the ability to regulate the type of T cell-mediated immune response.[34] In tumor immunity, DCs initially take up tumor-associated antigens in tumor tissue and presumably migrate to regional lymph nodes to generate tumor-specific immunity.[35] In detailed studies of CD4(+) CD25(+) FOXP3(+) T-reg cells in 104 individuals with ovarian carcinoma, Curiel et al found that human tumor T-reg cells suppress tumor-specific T cell immunity and contribute to the growth of human tumors in vivo.