FOXP4-AS1 lncRNA promotes cervical cancer cell proliferation, migration, and invasion through sponging miR-136–5p to regulate CBX4 expression.[20] Moreover, functional assays revealed that knockdown of FOXP4-AS1 efficiently suppressed esophageal squamous cell carcinoma cell proliferation and induced apoptosis.[21] Taken together, these findings suggest that FOXP4-AS1 may not only act as a potential therapeutic target, but also serve as a novel predictive biomarker of progression and prognosis of cancer. This evidence concerns the gene FOXP4 and esophageal squamous cell carcinoma.