Although pNETs are rare neoplasms, the incidence and prevalence have been steadily increasing.[1] pNETs include both functional pNETs with clinical syndromes caused by substances produced by the tumors and nonfunctional pNETs with no distinct clinical manifestations.[2] Functional pNETs may produce a variety of hormones, including insulin, gastrin, vasoactive intestinal polypeptide, glucagon, somatostatin, growth hormone-releasing hormone, and adrenocorticotropic hormone (ACTH).[3,4]. Here, POMC is linked to neoplasm.