Myb is known to promote the survival and proliferation of HSCs and leukemia stem cells (34–36); thus, we performed in vitro and in vivo assays, using Myb-depleted cells, to determine the impact of depleting Myb on the proliferation of HSPCs lacking p300 and TET2 (Supplemental Figure 5C). This evidence concerns the gene TET2 and leukemia.