IFNG and common variable immunodeficiency: Bacterial DNA effectively induced IFN-γ production in all study participants, but it induced significantly higher IFN-γ secretion in patients with CVID who had inflammatory conditions, as compared with other patients with CVID, patients with XLA, and healthy controls (mean 560.0 pg/mL, 197.7 pg/mL, 188.5 pg/mL, and 258.6 pg/mL, respectively, P < 0.0001, Figure 5C) in a dose-dependent manner (Supplemental Figure 6).