The results of IL-12p40–/–/ApoE–/– mice (39) show that proatherogenic IL-12p40 is responsible for the function of IL-12 (40), and the deficiency of IL-12p40 corresponding IL-12 receptor subunit IL12Rβ1 results in immunodeficiency (41). This evidence concerns the gene IL12RB1 and Immunodeficiency.