Several papers (9, 81) reported the plasticity of CCR5+ Tregs in the development of atherosclerosis, and one paper demonstrated that atherosclerosis drove the accumulation of an intermediate Th1-like IFNγ+CCR5+ Treg subset (Th1/Treg) within the aorta and peripheral lymph organs in 40 weeks of ApoE–/– mice (fed with chow diet) (9). This evidence concerns the gene CCR5 and atherosclerosis.