APOE and atherosclerosis: Taken together, our data have demonstrated that IL-35P35 deficiency in ApoE–/– mice decreases splenic Tregs, suggesting that IL-35 promotes splenic Tregs; IL-35 does not significantly change blood Tregs; and IL-35 promotion of splenic Tregs in ApoE–/– mice correlates well with IL-35 inhibition of atherosclerosis in ApoE–/– mice (30).